Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived Streptomyces sp

Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted a-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have been shown to have antibacterial and antitumor activities. However, the anti-inflammatory effe...

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Published inNatural product sciences Vol. 21; no. 4; pp. 251 - 254
Main Authors Lee, Hwa-Sun, An, Bong-Jeun, Kim, Hyeon Jeong, Cho, Yong Hun, Kim, Dong In, Jang, Jae Yoon, Kwak, Jae Hoon, Lee, Hyi-Seung, Lee, Yeon-Ju, Lee, Jong Seok, Shin, Hee Jae
Format Journal Article
LanguageEnglish
Published 한국생약학회 2015
Subjects
약학
α-Pyrones
Anti-inflammatory
Streptomyces sp
Violapyrones
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Summary:Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted a-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have been shown to have antibacterial and antitumor activities. However, the anti-inflammatory effect of violapyrones has not been reported yet. As part of our ongoing study for the discovery of bioactive metabolites from marine microorganisms, we found that violapyrones also have anti-inflammatory activity. In this study, we investigated the effect of violapyrones on LPS-induced inflammatory responses in vitro. Violapyrones B and C did not affect the viability of RAW 264.7 cells at concentrations up to 25 mM. However, violapyrones B and C inhibited the production of NO compared to the LPS-induced control. In addition, violapyrones B and C down-regulated the expression of iNOS protein in LPS-stimulated RAW 264.7 cells. To the best of our knowledge, this is the first report on the anti-inflammatory activity of violapyrones B and C. KCI Citation Count: 0
Bibliography:G704-001403.2015.21.4.004
ISSN:1226-3907
2288-9027
DOI:10.20307/nps.2015.21.4.251