Characterization of the mechanical behavior of human skin by means of impedance spectroscopy

• Published in: Journal of physics. Conference series Vol. 224; no. 1; p. 012131
• Main Authors: Pavšelj, N, Mitar, M, Hart, F X, Miklavčič, D
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.04.2010
• Subjects: Dielectric properties; Impedance spectroscopy; Mechanical properties; Multilayers; Parallel plates; Physics; Skin; Spectrum analysis; Thickness; Transdermal medication
• ISSN: 1742-6596; 1742-6588; 1742-6596
• DOI: 10.1088/1742-6596/224/1/012131

There is increased interest for the use of impedance spectroscopy to measure skin dielectric properties in vivo. The aim of such measurements can be either to evaluate the hydration state of the skin, to detect diseased states such as skin cancer, to follow the progress of transdermal drug delivery, or simply to gather data on skin tissue impedance to be used in theoretical studies. However, obtaining reliable data can be difficult. Namely, skin is a highly nonhomogeneous multi-layered structure whose composition and dimensions differ depending on the location on the body and interindividual variations. Also, impedance measurements on skin are accompanied by a number of artefacts. We performed a series of impedance measurements using an Agilent/HP 4284A precision LCR meter with parallel plate electrodes pressed on the skin, at different locations on the body. We observed substantial impedance changes over the course of the measurement. These changes can be mainly attributed to skin deformation caused by the electrodes pressing against skin. The analysis showed that skin mechanical properties and layer thicknesses can be inferred from these temporal changes. Such data on mechanical properties of skin tissue give valuable extra information, crucial for successful estimation of the impedance of different skin layers.