Design, synthesis and QSAR studies on N-aryl heteroarylisopropanolamines, a new class of non-peptidic HIV-1 protease inhibitors

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 10; no. 8; pp. 2511 - 2526
Main Authors DI SANTO, Roberto, COSTI, Roberta, ARTICO, Marino, MASSA, Silvio, RAGNO, Rino, MARSHALL, Garland R, LA COLLA, Paolo
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Science 01.08.2002
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
HIV-1 virus
Nitrogen heterocycle
Non peptide compound
Modeling
Pyrrole derivatives
Structure activity relation
Molecular model
Bicyclic compound
Comparative molecular field analysis method
Antiviral
Aromatic compound
Chemical synthesis
Aminoalcohol
Enzyme
Retroviridae
Enzyme inhibitor
Lentivirus
In vitro
Virus
Peptidases
Three dimensional model
Statistical model
Hydrolases
Human immunodeficiency virus
Indole derivatives
Protease inhibitor
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ISSN:0968-0896
1464-3391
DOI:10.1016/s0968-0896(02)00119-0