Compatibility of Heparin Sodium in Intravenous Line with Nicardipine Injected from a Side Tube via T-shape Stopcock

• Published in: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Vol. 38; no. 11; pp. 679 - 687
• Main Authors: Hayashi, Takafumi, Uwai, Koji, Sasaki, Eri, Sasaki, Keisuke, Iwabuchi, Yasushi, Agatsuma, Hitoshi, Suzuki, Tsuneyoshi
• Format: Journal Article
• Language: English
• Published: Japanese Society of Pharmaceutical Health Care and Sciences 10.11.2012
• Subjects: compatibility; heparin sodium; infusion; injection via T-shape stopcock; nicardipine
• ISSN: 1346-342X; 1882-1499
• DOI: 10.5649/jjphcs.38.679

The compatibility caused by injection of Nicarpine® 10 mg / 10 mL (Nicarpine®) from a side tube into an intravenous line infused with Replas® 1 Injection (Replas® 1) and Novo-Heparin® 10,000 units / 10 mL for Injection (Novo-Heparin®) was investigated. We observed a mixed solution of each constituent of Replas® 1 and Novo-Heparin® with Nicarpine®, and measured the IR spectrum of the precipitate and the 1H-NMR spectrum of a saturated solution of the mixture of heparin and nicardipine. Our findings suggested that the compatibility was caused by an intermolecular interaction between heparin and nicardipine when in a 1:2 ration via the formation of a salt between the sulfate group and/or the carboxylic group of heparin and the amino group of nicardipine.