Correlation between CD4^＋CD25^＋Treg Cells and CCR4 in Nasopharyngeal Carcinoma

OBJECTIVE CD4^＋CD25^＋ T regulatory （Treg） cells are a population of T cells which suppress an overactive immune system. CCR4 is a chemokine receptor involved in the recruitment of lymphocytes. Nasopharyngeal carcinoma （NPC） is resistant to immunosurveillance, owing to the increased number of tumor-i...

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Published inCancer biology & medicine Vol. 8; no. 2; pp. 106 - 113
Main Authors Ren, Yan-xin, Sui, Jun, Song, Xin, Wan Wong, Gee, Ma, Jing, Yao, Hong, Lin, Marie Chia-mi, Li, Xiao-jiang
Format Journal Article
LanguageEnglish
Published Heidelberg Tianjin Medical University Cancer Institute and Hospital 01.06.2011
China Anti-Cancer Association
Subjects
CCR4
CD4
CD4+CD25+ Treg cells
eg细胞
flow cytometry
Medicine
Medicine & Public Health
nasopharyngeal carcinoma
Oncology
tumor-infiltrating lymphocytes
免疫系统
淋巴细胞
肿瘤浸润
调节性T细胞
趋化因子受体
鼻咽癌
nasopharyngeal carcinoma
CD4
cells
T
tumor-infiltrating lymphocytes
flow cytometry
CD25
CCR4
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Summary:OBJECTIVE CD4^＋CD25^＋ T regulatory （Treg） cells are a population of T cells which suppress an overactive immune system. CCR4 is a chemokine receptor involved in the recruitment of lymphocytes. Nasopharyngeal carcinoma （NPC） is resistant to immunosurveillance, owing to the increased number of tumor-infiltrating Treg cells which are recruited to the tumor bv CCR4.
Bibliography:Yan-xin REN Jun SUI Xin SONG Gee WAN WONG Jing MA Hong YAO Marie Chia-mi LIN Xiao-jiang LI1 Immunotherapy Center, The Third Affiliated Hospital, Kunming Medical College, Kunming 650118, Yunnan Province, China. 2 Head and Neck Surgery, The Third Affiliated Hospital, Kunming Medical College, Kunming 650118, Yunnan Province, China. 3 Institute of Molecular Biology, Department of Chemistry, Open Laboratory of Chemical Biology, The University of Hong Kong, Hong Kong, China.
OBJECTIVE CD4^＋CD25^＋ T regulatory （Treg） cells are a population of T cells which suppress an overactive immune system. CCR4 is a chemokine receptor involved in the recruitment of lymphocytes. Nasopharyngeal carcinoma （NPC） is resistant to immunosurveillance, owing to the increased number of tumor-infiltrating Treg cells which are recruited to the tumor bv CCR4.
nasopharyngeal carcinoma, CD4^＋CD25^＋ Treg cells,CCR4, flow cytometry, tumor-infiltrating lymphocytes.
12-1404/R
ISSN:1674-5361
2095-3941
1868-324X
DOI:10.1007/s11805-011-0567-7