Comment on Lai et al. Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells. Int. J. Mol. Sci. 2023, 24 , 16101

• Published in: International journal of molecular sciences Vol. 25; no. 13; p. 7093
• Main Authors: Cordero, Oscar J, Kotrulev, Martin, Gomez-Touriño, Iria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.06.2024
• Subjects: Adipocytes; Adipocytes - drug effects; Adipocytes - metabolism; adipogenesis; Adipogenesis - drug effects; Adipogenesis - genetics; adiponectin; Adiponectin - genetics; Adiponectin - metabolism; Adipose Tissue - metabolism; Angiogenesis; Animals; Body fat; CCL2; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; Chemokines; Conflicts of interest; Diabetes; Dipeptidyl Peptidase 4 - genetics; Dipeptidyl Peptidase 4 - metabolism; DPP4; Enzymes; Gene expression; Gene Expression Regulation - drug effects; Heparan sulfate; Humans; Immune system; Inflammation; Insulin resistance; Leukemia; Ligands; Liver cancer; Metabolic syndrome; Obesity; PAR-2; Proteins; Smooth muscle; Stem cells; Stromal Cells - metabolism; DPP4; PAR-2; adiponectin; stem cells; CCL2; adipogenesis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25137093

Adiponectin is a circulating hormone secreted by adipose tissue that exerts, unlike other adipokines such as leptin, anti-inflammatory, anti-atherosclerotic and other protective effects on health. Adiponectin receptor agonists are being tested in clinical trials and are expected to show benefits in many diseases. In a recent article, LW Chen's group used monocyte chemoattractant protein-1 (MCP-1/CCL2) to improve plasma levels of adiponectin, suggesting the involvement of dipeptidyl peptidase 4 (DPP4/CD26) in the mechanism. Here, we discuss the significance of the role of DPP4, favoring the increase in DPP4-positive interstitial progenitor cells, a finding that fits with the greater stemness and persistence of other DPP4/CD26-positive cells.