Encapsulation of α-lipoic acid intochitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity
Alpha-lipoic acidis an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of ?-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, ?-lipoic acid w...
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Published in | Hemijska industrija Vol. 70; no. 1; pp. 49 - 58 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English Serbian |
Published |
Belgrade
Hemijska Industrija
2016
Association of Chemical Engineers of Serbia |
Subjects | |
Online Access | Get full text |
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Summary: | Alpha-lipoic acidis an organosulphur compound well-known for its therapeutic
potential and antioxidant properties. However, the effective use of ?-lipoic
acid depends on biological plasma half-life and its preserving stability,
which could be improved by encapsulation. In this study, ?-lipoic acid was
incorporated into chitosan microparticles obtained by reverse emulsion
crosslinking technique, as well as into microparticles of alginate/gelatin
crosslinked with zinc ions. Encapsulation of ?-lipoic acid in both cases was
carried out by swelling of synthesized dried microparticles by their dipping
in a solution of the active substance under strictly controlled conditions.
Encapsulation efficiency of ?-lipoic acid obtained in this study was up to
53.9 %. The structural interaction of ?-lipoic acid with the carriers was
revealed by Fourier transform infrared spectroscopy. In vitro released
studies showed that controlled release of ?-lipoic acid was achieved through
its encapsulation into chitosan microparticles. The results of in vitro
antioxidative activity assays of released ?-lipoic acid indicated that
antioxidant activity was preserved at a satisfactory level. These obtained
results suggested that chitosan microparticles could be suitable for modeling
the controlled release of ?-lipoic acid. |
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ISSN: | 0367-598X 2217-7426 |
DOI: | 10.2298/HEMIND141119010V |