High-sensitivity C-reactive protein in Sri Lankan males with coronary artery disease

• Published in: Bangladesh journal of medical science (Ibn Sina Trust) Vol. 15; no. 1; pp. 44 - 50
• Main Authors: Wickramatilake, Chandima Madhu, Mohideen, Mohamad Rifdy, Pathirana, Chitra
• Format: Journal Article
• Language: English
• Published: Dhaka Ibn Sina Trust 01.01.2016
• ISSN: 2223-4721; 2076-0299
• DOI: 10.3329/bjms.v15i1.19736

Objectives: Evidence suggests that inflammation and dyslipideamia play a key role in the pathogenesis of coronary artery disease (CAD). High sensitivity C-reactive protein (hs- CRP) is a sensitive marker of inflammation. We attempted to evaluate the contribution of dyslipidaemia and inflammation in CAD.Materials and methods: Three hundred and nine males (103 with myocardial infarction - MI, 103 with established CAD, 103 healthy controls) were studied. The serum hs-CRP, lipids and plasma glucose were determined.Results: Baseline mean hs-CRP levels in patients with established CAD and MI were significantly higher compared to controls (3.4 ± 1.62 VS. 1.70 ± 0.60 mg/L, p = 0.001) (3.7 ± 0.65 VS. 1.70 ± 0.60 mg/L, p = 0.001). A significant negative correlation observed between hs-CRP and HDL-Ch (r = -0.359, p = 0.001).Conclusion: Inflammation (which was reflected by elevated hs-CRP) and dyslipidamia were associated with coronary artery disease.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.44-50