βig-h3 supports keratinocyte adhesion, migration, and proliferation through α3β1 integrin

βig-h3 is an extracellular matrix protein and its expression is highly induced by TGF-β and it has also been suggested to play important roles in skin wound healing. In this paper, we demonstrate that βig-h3 is present in the papillary layer of dermis and synthesized in the basal keratinocytes in vi...

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Published inBiochemical and biophysical research communications Vol. 294; no. 5; pp. 940 - 948
Main Authors Bae, Jong-Sup, Lee, Suk-Hee, Kim, Jung-Eun, Choi, Je-Yong, Park, Rang-Woon, Yong Park, Jae, Park, Hyun-Sook, Sohn, Young-Sook, Lee, Dong-Sin, Bae Lee, Eunhee, Kim, In-San
Format Journal Article
LanguageEnglish
Published Elsevier Inc 28.06.2002
Subjects
Cell adhesion
Keratinocyte
Migration
TGF-β
Wound healing
α3β1 Integrin
βig-h3
Wound healing
Migration
βig-h3
Cell adhesion
α3β1 Integrin
Keratinocyte
TGF-β
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Summary:βig-h3 is an extracellular matrix protein and its expression is highly induced by TGF-β and it has also been suggested to play important roles in skin wound healing. In this paper, we demonstrate that βig-h3 is present in the papillary layer of dermis and synthesized in the basal keratinocytes in vivo and its expression is induced by TGF-β in normal human keratinocytes (NHEK) and HaCaT cells. βig-h3 mediates not only adhesion and spreading of keratinocytes but also supports migration and proliferation. These activities are mediated through interacting with α3β1 integrin. Previously identified two α3β1 integrin-interacting motifs of βig-h3, EPDIM, and NKDIL, are responsible for these activities. The results suggest that βig-h3 may regulate keratinocyte functions in normal skin and potentially during wound-healing process.
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(02)00576-4