Palladium-catalyzed arylation of ureas

Urea arylation with aryl halides in the presence of catalyst precursor Pd(2)dba(3)-CHCl3/Xantphos and Cs2CO3 in dioxane at 100degreesC affords symmetrical N,N-diarylureas in 64-92% yield. With the same catalytic system the reaction between N-phenylurea and aryl bromides containing electron-withdrawi...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 38; no. 4; pp. 538 - 545
Main Authors Artamkina, GA, Sergeev, AG, Beletskaya, IP
Format Journal Article
LanguageEnglish
Published NEW YORK MAIK NAUKA/INTERPERIODICA 01.04.2002
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
AMINATION
LIGANDS
AMINES
ARYL HALIDES
COMPLEXES
CHLORIDES
NITROGEN
BOND FORMATION
N-ARYLATION
BROMIDES
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Summary:Urea arylation with aryl halides in the presence of catalyst precursor Pd(2)dba(3)-CHCl3/Xantphos and Cs2CO3 in dioxane at 100degreesC affords symmetrical N,N-diarylureas in 64-92% yield. With the same catalytic system the reaction between N-phenylurea and aryl bromides containing electron-withdrawing substituents in the para-position provided N-aryl-N'-phenylureas in 64-91% yields.
ISSN:1070-4280
DOI:10.1023/A:1016503307552