Changes in plasma volume, in transcapillary escape rate of albumin and in subcutaneous blood flow during hypoglycaemia in man

• Published in: Clinical science (1979) Vol. 69; no. 3; pp. 273 - 277
• Main Authors: HILSTED, J, BONDE-PETERSEN, F, MADSBAD, S, PARVING, H.-H, CHRISTENSEN, N. J, ADELHØJ, B, BIGLER, D, SJØNTOFT, E
• Format: Journal Article
• Language: English
• Published: London Portland Press 01.09.1985
• Subjects: Adult; Biological and medical sciences; Blood Glucose - analysis; Blood Pressure; Capillary Permeability; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Heart Rate; Humans; Male; Medical sciences; Plasma Volume; Regional Blood Flow; Serum Albumin - metabolism; Skin - blood supply; Skin Temperature; Space life sciences; Tumors. Hypoglycemia; Human; Volume; Albumin; Metabolic diseases; Blood capillary; Carbohydrate; Hypoglycemia; Blood
• ISSN: 0143-5221; 1470-8736
• DOI: 10.1042/cs0690273

Hypoglycaemia was induced by insulin injected intravenously (0.15 i.u./kg body weight) in seven healthy young males. Plasma volume was measured before and during hypoglycaemia by intravenous injection of 125I before hypoglycaemia and of 131I during hypoglycaemia. Plasma volume decreased and transcapillary escape rate increased significantly during hypoglycaemia. Skin temperature and local subcutaneous adipose tissue blood flow were measured in four different regions. Both tended to decrease during hypoglycaemia and decreased significantly 2 h after hypoglycaemia. There was no correlation between changes in the two measurements, suggesting that there is no simple relationship between subcutaneous blood flow and skin temperature during hypoglycaemia.