Pylephlebitis treated with apixaban

Pylephlebitis is a rare condition that is characterized by an infected thrombus of the portal vein system and was traditionally associated with a high mortality rate prior to the introduction of antibiotics. This report details a 77-year-old Chinese male found to have a splenic vein thrombosis, bact...

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Published inHospital practice (1995) Vol. 47; no. 4; p. 192
Main Authors Hale, Graham R, Sakkal, Leon Alan, Galanis, Taki
Format Journal Article
LanguageEnglish
Published England 01.10.2019
Subjects
Aged
Bacteremia - drug therapy
Bacteremia - microbiology
Drainage
Factor Xa Inhibitors - therapeutic use
Firmicutes
Humans
Male
Pyrazoles - therapeutic use
Pyridones - therapeutic use
Splenic Vein
Thrombophlebitis - drug therapy
Thrombophlebitis - microbiology
splenic vein
thrombosis
anticoagulant
Pylephlebitis
apixaban
parvinomonas
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Summary:Pylephlebitis is a rare condition that is characterized by an infected thrombus of the portal vein system and was traditionally associated with a high mortality rate prior to the introduction of antibiotics. This report details a 77-year-old Chinese male found to have a splenic vein thrombosis, bacteremia, and a polymicrobial splenic abscess. The patient was treated with abscess drainage and a 6 week course of intravenous antibiotics, and a direct oral anticoagulant, apixaban 2.5 mg twice daily. To our knowledge, this is the second documented case of pylephlebitis treated with apixaban. Here, we summarize our experience treating this case of pylephlebitis and briefly report on the existing body of literature.
ISSN:2154-8331
DOI:10.1080/21548331.2019.1670476