Atrial natriuretic factor: is it responsible for hyponatremia and natriuresis in neurosurgery?

To evaluate the presence of hyponatremia and natriuresis and their association with atrial natriuretic factor in neurosurgery patients. The study included 30 patients who had been submitted to intracranial tumor resection and cerebral aneurism clipping. Both plasma and urinary sodium and plasma atri...

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Published inRevista Brasileira de terapia intensiva Vol. 28; no. 2; pp. 154 - 160
Main Authors Gasparotto, Ana Paula Devite Cardoso, Falcão, Antonio Luis Eiras, Kosour, Carolina, Araújo, Sebastião, Cintra, Eliane Araújo, Oliveira, Rosmari Aparecida Rosa Almeida de, Martins, Luiz Claudio, Dragosavac, Desanka
Format Journal Article
LanguageEnglish
Published Brazil Associação de Medicina Intensiva Brasileira - AMIB 01.06.2016
Subjects
Adult
Atrial Natriuretic Factor - blood
Brain Neoplasms - surgery
Female
Humans
Hyponatremia - epidemiology
Intracranial Aneurysm - surgery
Male
Middle Aged
Natriuresis - physiology
Neurosurgical Procedures - methods
Original
Postoperative Period
Preoperative Period
Prospective Studies
Sodium - urine
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Summary:To evaluate the presence of hyponatremia and natriuresis and their association with atrial natriuretic factor in neurosurgery patients. The study included 30 patients who had been submitted to intracranial tumor resection and cerebral aneurism clipping. Both plasma and urinary sodium and plasma atrial natriuretic factor were measured during the preoperative and postoperative time periods. Hyponatremia was present in 63.33% of the patients, particularly on the first postoperative day. Natriuresis was present in 93.33% of the patients, particularly on the second postoperative day. Plasma atrial natriuretic factor was increased in 92.60% of the patients in at least one of the postoperative days; however, there was no statistically significant association between the atrial natriuretic factor and plasma sodium and between the atrial natriuretic factor and urinary sodium. Hyponatremia and natriuresis were present in most patients after neurosurgery; however, the atrial natriuretic factor cannot be considered to be directly responsible for these alterations in neurosurgery patients. Other natriuretic factors are likely to be involved.
Bibliography:Conflicts of interest: None.
ISSN:0103-507X
1982-4335
DOI:10.5935/0103-507X.20160030