Structure determination of two new C-21 steroidal glycosides from Cynanchum komarovii

Two new 13,14:14,15-disecopregnane-type C-21 steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3-6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucid...

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Published inJournal of asian natural products research Vol. 20; no. 9; pp. 852 - 859
Main Authors Zhao, Dan, Tang, Ming-Xu, Su, Shan-Shan, Lu, Xiao-Jie, Wang, Yu-Bo, Chen, Shao-Fei, Wang, Hai-Feng, Chen, Gang, Pei, Yue-Hu
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 02.09.2018
Subjects
Chemistry
Chemistry, Applied
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
Science & Technology
ROOTS
Cynanchum komarovii
C-21 steroidal glycoside
komaroside R
komaroside S
Asclepiadaceae
C steroidal glycoside
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Summary:Two new 13,14:14,15-disecopregnane-type C-21 steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3-6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC50 values being 6.2 and 17.6M, respectively, compared to the positive control 5-fluorouracil (6.4M). [GRAPHICS] .
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2017.1396977