Synthesis of 5-Carbonyl-1,3-dihydro- 1,3-dioxo-2H-isoindole-2-propanoic Acid Integrin Antagonists

The 5-carboxy-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid benzyl ester (I), obtained from condensation of 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid with β-alanine benzyl ester p-toluenesulfonate, reacted with an appropriate amine (II) to afford the corresponding amide (IIIa-e), wh...

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Bibliographic Details
Published inSynthetic communications Vol. 33; no. 12; pp. 2109 - 2117
Main Authors Deng, Yong, Shen, Yi, Zhong, Yu-Guo
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.07.2003
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Summary:The 5-carboxy-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid benzyl ester (I), obtained from condensation of 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid with β-alanine benzyl ester p-toluenesulfonate, reacted with an appropriate amine (II) to afford the corresponding amide (IIIa-e), which then hydrogenolyzed by 5% palladium-on-carbon to give target compounds (IVa-e).
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120021037