Clinical-pathologic correlation: The impact of grossing at the bedside

The unenlightened clinician may submit a skin specimen to the lab and expect an “answer.” The experienced clinician knows that in performing skin biopsies, it is critical to select the most appropriate: 1) anatomic location for the biopsy1,2; 2) type of biopsy1,2; 3) depth and breadth of the biopsy;...

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Bibliographic Details
Published inSeminars in diagnostic pathology
Main Authors Noble, C. Alexis, Bhate, Chinmoy, Duong, Buu T., Cruse, Allison R., Brodell, Robert T., Hanus, Riley C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 05.01.2024
Subjects
Blisters
Grossing
Pemphigoid
Porokeratosis
Punch biopsy
Vitiligo
Grossing
Blisters
Porokeratosis
Pemphigoid
Vitiligo
Punch biopsy
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Summary:The unenlightened clinician may submit a skin specimen to the lab and expect an “answer.” The experienced clinician knows that in performing skin biopsies, it is critical to select the most appropriate: 1) anatomic location for the biopsy1,2; 2) type of biopsy1,2; 3) depth and breadth of the biopsy; and 4) medium for hematoxylin and eosin staining (formalin) or direct immunofluorescence (Michel's Transport Medium or normal saline).2 Demographic information, anatomic location, clinical context, and differential diagnosis are all critical components of a properly completed requisition form.3–5 Proper biopsy design and appropriate grossing of the tissue at the bedside should be added to this list. In this article, we review the basics of gross pathologic examination and then provide four examples to demonstrate that optimal clinical-pathologic correlation requires the clinician consider the needs of the pathologist when tissue is presented to the lab.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0740-2570
1930-1111
DOI:10.1053/j.semdp.2024.01.007