Combination Therapy of Hepatic Resection and Radiofrequency Ablation for Primary Hepatic Carcinoid Tumor with Multiple Intrahepatic Metastases; Report of a Case

• Published in: Nippon Shokaki Geka Gakkai zasshi Vol. 41; no. 2; pp. 200 - 205
• Main Authors: Nakamura, Noboru, Komokata, Teruo, Hamada, Nobuo, Iwashita, Ryuji, Kudama, Teruaki, Fukukura, Yoshihiko, Kitajima, Shinichi, Sakata, Ryuzo
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society of Gastroenterological Surgery 2008
• Subjects: hepatic resection; primary hepatic carcinoid tumors; radiofrequency ablation
• ISSN: 0386-9768; 1348-9372
• DOI: 10.5833/jjgs.41.200

A 55-year-old man with epigastric pain and admitted to treat multiple liver masses was found in preoperative ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) to have a solid 10cm mass with cystic components in the left lateral segment and multiple small masses in bilateral lobes. Angiography showed a hypervascular mass supplied by the left hepatic artery. We conducted left hepatic lobectomy, partial resection, and radiofrequency ablation (RFA) for all tumors. The resected specimen was a solid tumor with cystic components and a hemorrhagic lesion. Light-microscopy findings showed the tumor to have trabecular, glandular, and rosette structures. Immunohistochemically, tumor cells stained positive for neuronspecific enolase (NSE) and synaptophysin, and stained focally positive for chromogranin A and grimelius. Careful pre- and postoperative examination showed no other tumor origin. In careful follow-up for the primary hepatic carcinoid tumor, the man continues without recurrence in the 6 years since surgery. We report a rare case of primary hepatic carcinoid tumor with a discussion of the literature.