Stereospecific ligands and their complexes, Part VIII: Antimicrobial activity of palladium(II) complexes with 0,0'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid

• Published in: Hemijska industrija Vol. 66; no. 3; pp. 349 - 355
• Main Authors: Ilic, Dragoslav, Vujic, Jelena, Radojevic, Ivana, Stefanovic, Olgica, Comic, Ljiljana, Bankovic, Dragic, Trifunovic, Srecko
• Format: Journal Article
• Language: English; Serbian
• Published: Belgrade Hemijska Industrija 2012; Association of Chemical Engineers of Serbia
• Subjects: Antiinfectives and antibacterials; antimicrobial activity; Antimicrobial agents; Bacteria; Coordination compounds; electronic absorption spectra; Esters; Ethylenediamine; Ligands; Palladium; palladium(II) complexes
• ISSN: 0367-598X; 2217-7426
• DOI: 10.2298/HEMIND110928096I

Palladium(II) complexes (1-4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N?-ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N?-di-2-(4-methyl)pentanoic acid (S,S-eddp) were prepared and characterized by microanalysis, infrared and UV/VIS spectroscopy. The ligands and its complexes were tested for their in vitro antimicrobial activity against 15 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. The MIC values were in range from 4.9 ?g cm-3 to > 5000 ?g cm-3 while MMC values ranged from 78 ?g cm-3 to > 5000 ?g cm-3. Palladium(II) complexes [PdCl2(Ln)] (n = 1-4) have statistically significant higher activity than the corresponding ligands. The complex 4 displayed the strongest activity among all tested compounds. nema