Dereplication and evaluation of the antinociceptive and anti-inflammatory activity of hydroethanolic extract of leaves from Campomanesia xanthocarpa O. Berg

Campomanesia xanthocarpa popularly known as gabiroba is used as a medicinal plant for the treatment of inflammatory diseases, ulcers, among other uses, requiring studies to assist in proving these activities. In this study, the extract of leaves from C. xanthocarpa (CxHE) was submitted to assays of...

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Published inNatural product research Vol. 35; no. 23; pp. 5549 - 5553
Main Authors Leandro, Fabrício Damasceno, Cabral, Layla Dutra Marinho, Machado, Tallita Marques, Koolen, Hector Henrique Ferreira, da Silva, Felipe Moura Araújo, Guilhon-Simplicio, Fernanda, da Silva, Marcelo Aparecido, Giusti-Paiva, Alexandre, Moura, Clarice de Carvalho Veloso, da Silva, Geraldo Alves
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis Ltd 01.12.2021
Subjects
Anti-inflammatory agents
Campomanesia xanthocarpa
Carrageenan
Chemical analysis
Epigallocatechin gallate
Flavonoids
Gallic acid
Herbal medicine
In vivo methods and tests
Inflammatory diseases
Leaves
Lipopolysaccharides
Liquid chromatography
Medicinal plants
Pain perception
Peritonitis
Phenols
Protocatechuic acid
Quercetin
Saponins
Steroid hormones
Triterpenoids
Ulcers
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Summary:Campomanesia xanthocarpa popularly known as gabiroba is used as a medicinal plant for the treatment of inflammatory diseases, ulcers, among other uses, requiring studies to assist in proving these activities. In this study, the extract of leaves from C. xanthocarpa (CxHE) was submitted to assays of formalin-induced paw-licking, peritonitis induced by lipopolysaccharide and carrageenan-induced mechanical hyperalgesia tests. In chemical analysis, a preliminary phytochemical screening and the determination of phenol and flavonoid content were carried out, in addition to analysis by ESI-MS/MS system and HPLC-DAD system. The CxHE presented compounds such as tannins, triterpenoids, steroids and saponins and content of phenols (35.9 ± 1.3 GAE/g extract) and flavonoids (23.3 ± 2.1 mg EQ/g extract). Protocatechuic acid, gallic acid, ethyl gallate, quercetin, and 3-methyl epigallocatechin gallate, alpha and beta-amyrins were identified. CxHE at doses of 10-1000 mg/kg p.o. demonstrated anti-inflammatory and antinociceptive effects in all in vivo assays employed in this study.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1795654