2003 Mixed meal effects of neprilysin inhibition

OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/...

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Bibliographic Details
Published inJournal of clinical and translational science Vol. 2; no. S1; p. 44
Main Authors Wilson, Jessica R., Rader, Daniel, Townsend, Raymond, Rickels, Michael
Format Journal Article
LanguageEnglish
Published Cambridge Cambridge University Press 01.06.2018
Subjects
Basic/Translational Science/Team Science
Blood pressure
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Neprilysin
Population studies
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Summary:OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/ANTICIPATED RESULTS: We anticipate higher intact GLP-1 area under the cure after the meal when subjects receive sacubitril/valsartan compared with valsartan. DISCUSSION/SIGNIFICANCE OF IMPACT: Neprilysin inhibition may be a target for anti-diabetes therapy by decreasing degradation of GLP-1.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2059-8661
2059-8661
DOI:10.1017/cts.2018.171