Effect of Gabapentin on Tendon-to-Bone Healing in a Rat Model of Rotator Cuff Repair

• Published in: Orthopedics (Thorofare, N.J.) Vol. 47; no. 5; pp. e241 - 6
• Main Authors: Chung, Seok Won, Chung, Seung Ho, Kim, Dong-Hyun, Lee, Hyun Joo, Park, Eugene Jae Jin, Shim, Bum-Jin, Kim, Du Han, Yoon, Jong Pil
• Format: Journal Article
• Language: English
• Published: United States Slack, Inc 01.09.2024; SLACK INCORPORATED
• Subjects: Analgesics; Analgesics - therapeutic use; Animals; Biomechanical Phenomena; Biomechanics; Brachial plexus; Care and treatment; Collagen; Diagnosis; Disease Models, Animal; Dosage and administration; Fractures; Gabapentin; Gabapentin - pharmacology; Gabapentin - therapeutic use; Male; Narcotics; Pain; Pain management; Patient outcomes; Rats; Rats, Sprague-Dawley; Rotator cuff; Rotator Cuff - surgery; Rotator Cuff Injuries - drug therapy; Rotator Cuff Injuries - surgery; Rotator cuff repair; Shoulder; Shoulder injuries; Statistical analysis; Surgery; Wound Healing - drug effects; South Korea
• ISSN: 0147-7447; 1938-2367; 1938-2367
• DOI: 10.3928/01477447-20240718-01

Gabapentin is often used as an analgesic after rotator cuff repair surgery and is recommended as an additional analgesic for arthroscopic rotator cuff repairs. However, evidence of its effects on biological healing mechanisms is lacking. The objective of this study was to investigate the potential of gabapentin in improving tendon-to-bone healing after rotator cuff repair using a rat model. A total of 20 male rats were randomly allocated to one of two groups: group 1 (repair only, n=10) or group 2 (gabapentin injection, n=10). The rats in the experimental group (group 2) were administered 80 mg/kg of gabapentin subcutaneously 30 minutes before surgery, followed by 80 mg/kg subcutaneously every 24 hours for 48 hours. We used the left shoulder of every rat, while for biomechanical analysis, we used the right shoulder. There was no significant difference in the load to failure, ultimate stress, or elongation between the groups. Collagen continuity, orientation, and density were better in group 2 than group 1. In a rat model of rotator cuff repair, gabapentin had a positive impact on the quality of collagen organization at the junction between the tendon and bone, while preserving the biomechanical properties. We propose the use of gabapentin as a supplementary analgesic agent for postoperative pain relief after arthroscopic rotator cuff repair; however, further studies of the effect of gabapentin on biological healing mechanisms are required. [ . 2024;47(5):e241-e246.].