Retransfusion acidosis after haemorrhagic hypotension in dogs
Anaesthetized dogs subjected to severe haemorrhagic hypotension followed by spontaneous uptake of 30 per cent of the shed blood were studied. One group was then transfused with blood, another with low molecular weight dextran, and a third with Locke's solution. During the hypotensive phase, the...
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Published in | Injury Vol. 5; no. 3; pp. 239 - 243 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
1974
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Subjects | |
Online Access | Get full text |
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Summary: | Anaesthetized dogs subjected to severe haemorrhagic hypotension followed by spontaneous uptake of 30 per cent of the shed blood were studied. One group was then transfused with blood, another with low molecular weight dextran, and a third with Locke's solution. During the hypotensive phase, the arterial
pH, standard bicarbonate, buffer base and
Pco
2 fell, while the lactate, pyruvate, and potassium values rose. Within half a minute of retransfusion, the
pH decreased further but the
Pco
2 rose to normal or higher values. The greatest fall in
pH occurred in the dextran group, but the
pH of dextran is lower than that of the reinfused blood or Locke's solution.
The fall in
pH and rise in
Pco
2 after retransfusion occur with unchanged lactate levels and so cannot be attributed to ‘washout’ of lactate from the tissues. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0020-1383 1879-0267 |
DOI: | 10.1016/S0020-1383(74)80016-1 |