Usefulness of Cardiac Sympathetic Nerve Imaging Using 123Iodine-Metaiodobenzylguanidine Scintigraphy for Predicting Sudden Cardiac Death in Patients With Heart Failure

The autonomic nervous system plays an important role in the human heart. Activation of the cardiac sympathetic nervous system is a cardinal pathophysiological abnormality associated with the failing human heart. Myocardial imaging using 123I-metaiodobenzylguanidine (MIBG), an analog of norepinephrin...

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Bibliographic Details
Published inInternational Heart Journal Vol. 57; no. 2; pp. 140 - 144
Main Authors Kasama, Shu, Toyama, Takuji, Kurabayashi, Masahiko
Format Journal Article
LanguageEnglish
Published International Heart Journal Association 2016
Subjects
Nuclear imaging
Prognostic value
Sympathetic nervous system
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Summary:The autonomic nervous system plays an important role in the human heart. Activation of the cardiac sympathetic nervous system is a cardinal pathophysiological abnormality associated with the failing human heart. Myocardial imaging using 123I-metaiodobenzylguanidine (MIBG), an analog of norepinephrine, can be used to investigate the activity of norepinephrine, the predominant neurotransmitter of the sympathetic nervous system. Many clinical trials have demonstrated that 123I-MIBG scintigraphic parameters predict cardiac adverse events, especially sudden cardiac death, in patients with heart failure. In this review, we summarize results from published studies that have focused on the use of cardiac sympathetic nerve imaging using 123I-MIBG scintigraphy for risk stratification of sudden cardiac death in patients with heart failure.
ISSN:1349-2365
1349-3299
DOI:10.1536/ihj.15-508