An Ultrastructural Study on the Effect of Ipriflavone and Calcitonin on Debilitated Mandibular Condyle

• Published in: The Journal of The Kyusyu Dental Society Vol. 56; no. 5; pp. 187 - 200
• Main Authors: Wang, Jianguo, Nishioka, Takahiro, Xia, Bin, Hitaka, Akiko, Nishikawa, Yasuhiro, Ge, Lihong, Kimura, Mitsutaka
• Format: Journal Article
• Language: English; Japanese
• Published: KYUSHU DENTAL SOCIETY 25.10.2002; Kyushu Dental Society
• Subjects: Calcitonin; Ipriflavone; Mandibular Condyle; Rats
• ISSN: 0368-6833; 1880-8719
• DOI: 10.2504/kds.56.187

In this study, 5-week-old rats, corresponding to the childhood in human, were used. The aim of this study was to observe the effect of Ipriflavone (IF) and Eel Calcitonin (ECT) on debilitated mandibular condyle. The ultrastructural results were as follows. 1. Light microscope finding The finding of ECT-IF group were similar to those of the control group, in that the number of trabeculae increase, the osteoblasts lined on the bone surface markedy, and the growth of mandibular condyle showed accelerated. 2. Scanning electron microscope findings In ECT-IF group, the territorial matrix, agglutinations of calcospherite and distinct chondral lacunae were found, as seen in the control group. The collagen fiber around calcospherite arranged regularly. In bone matrix, the areas of bone formation were often seen, and distinct borders of osteocyte lacunae and canaliculi were found. 3. Transmission electron microscopy findings The characteristic of ECT-IF group was the osteoclasts were inactive and the ruffled borders were poorly developed. The osteoblasts were active. The whole finding of the group was similar to the control group. In conclusion, debilitated mandibular condyle resulting from insufficient calcium intake in developmental period could be recovered by dietary therapy using 1α-OH-D_3 and ipriflavone supplementary standard diet.