Type-C oncovirus isolate from human leukemic bone marrow: further in vitro and in vivo characterization

Rabbit corneal cells transformed by a putative human type-C helper virus pseudotype of the mouse sarcoma virus produce large amounts of transforming and non-transforming viruses. The virions are antigenically related to the woolly monkey (simian) sarcoma-leukemia type-C oncovirus. Typical sarcoma vi...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of cancer Vol. 21; no. 1; p. 27
Main Authors Nooter, K, Overdevest, J, Dubbes, R, Koch, G, Bentvelzen, P, Zurcher, C, Coolen, J, Calafat, J
Format Journal Article
LanguageEnglish
Published United States 15.01.1978
Subjects
Animals
Biological Assay
Bone Marrow - microbiology
Bone Marrow Cells
Cell Line
Cell Transformation, Viral
Fluorescent Antibody Technique
Guinea Pigs
Humans
Immune Sera
Immunoenzyme Techniques
Isoelectric Focusing
Leukemia - microbiology
Microscopy, Electron
Rats
Retroviridae - immunology
Retroviridae - isolation & purification
Sarcoma, Experimental - etiology
Viral Plaque Assay
Online AccessGet more information

Cover

More Information
Summary:Rabbit corneal cells transformed by a putative human type-C helper virus pseudotype of the mouse sarcoma virus produce large amounts of transforming and non-transforming viruses. The virions are antigenically related to the woolly monkey (simian) sarcoma-leukemia type-C oncovirus. Typical sarcoma virus lesions developed in newborn rats injected with virus-producing rabbit cells. Cells producing only the putative type-C helper viruses as a result of exposure to a high dilution of transforming virus stock induce lymphosarcomas after inoculation into newborn rats.
ISSN:0020-7136
DOI:10.1002/ijc.2910210107