Heterogeneity of obesity phenotypes in relation to cardiovascular risk

• Published in: Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika Vol. 18; no. 1; pp. 161 - 167
• Main Authors: Druzhilov, М. A., Kuznetsova, Т. Yu
• Format: Journal Article
• Language: English
• Published: SILICEA-POLIGRAF» LLC 01.03.2019
• Subjects: cardiovascular risk; metabolically healthy obesity; obesity phenotype; visceral obesity
• ISSN: 1728-8800; 2619-0125
• DOI: 10.15829/1728-8800-2019-1-161-167

Obesity is associated with numerous metabolic disorders, the development and progression of a wide range of conditions and diseases, primarily cardiovascular disease and type 2 diabetes. One of the widely discussed phenomena of the association of obesity with cardiovascular diseases, their complications and mortality is the phenomenon of “heterogeneity of obesity phenotypes in relation to cardiovascular risk”. Currently, two main phenotypes have been identified — metabolically healthy and metabolically unhealthy obesity. At the same time, not only the expediency of separation, but also the existence of this phenotype is widely discussed today. The article provides an overview of existing approaches to the verification of metabolic phenotypes of obesity and data relating to the epidemiology and the association of metabolically healthy obesity with the risk of cardiovascular diseases and death, and also discusses the factors that determine the features of the obesity phenotype.