Botulinum Toxin A in the Treatment of Chromhidrosis

Background. Chromhidrosis is an uncommon disorder characterized by secretion of colored sweat by apocrine glands, typically localized to the face or axilla. The current treatments available for chromhidrosis are time consuming and frequently ineffective. Objective. Our purpose is to demonstrate a no...

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Bibliographic Details
Published inDermatologic surgery Vol. 31; no. 8; pp. 963 - 965
Main Authors Wu, Jessie M., Mamelak, Adam J., Nussbaum, Rachel, McElgunn, Patrick S. J.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.08.2005
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Summary:Background. Chromhidrosis is an uncommon disorder characterized by secretion of colored sweat by apocrine glands, typically localized to the face or axilla. The current treatments available for chromhidrosis are time consuming and frequently ineffective. Objective. Our purpose is to demonstrate a novel approach to the treatment of apocrine chromhidrosis. Methods. We report a case of apocrine chromhidrosis successfully treated with botulinum toxin A (BTX‐A; Botox). Results. BTX‐A therapy successfully controlled facial chromhidrosis, and the effects were visible at 19 weeks post‐treatment. The therapeutic benefits may be attributed to its inhibitory effects on cholinergic stimulation, adrenergic stimulation, and substance P release, although further studies are necessary to elucidate the precise mechanism of action. Conclusion. This report demonstrates a new therapeutic approach to patients suffering from chromhidrosis.
Bibliography:JESSIE M. WU, ADAM J. MAMELAK, MD, RACHEL NUSSBAUM, MD, AND PATRICK S. J. MCELGUNN, MD, MBA, HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.
ISSN:1076-0512
1524-4725
DOI:10.1111/j.1524-4725.2005.31814