Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants

The aim of the paper was to obtain a stable micellar emulsion of potent photosensitizer (PS) – O-propyloxime-N-propoxybacteriopurpurinimide methyl ester absorbing light in long-wave region of the spectrum (λmax = 800±2 нм). Solubilizates of the dye based on different surfactants (Kolliphor ELP, Polo...

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Published inBiomedical Photonics Vol. 8; no. 1; pp. 18 - 23
Main Authors E. A. Plotnikova, V. O. Stramova, N. B. Morozova, A. D. Plyutinskaya, P. V. Ostroverkhov, M. A. Grin, A. F. Mironov, R. I. Yakubovskaya, A. D. Kaprin
Format Journal Article
LanguageEnglish
Published Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" 01.04.2019
Subjects
bacteriochlorin
emulsion
photodynamic therapy
photosensitizer
solubilizer
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Summary:The aim of the paper was to obtain a stable micellar emulsion of potent photosensitizer (PS) – O-propyloxime-N-propoxybacteriopurpurinimide methyl ester absorbing light in long-wave region of the spectrum (λmax = 800±2 нм). Solubilizates of the dye based on different surfactants (Kolliphor ELP, Poloxamer 407, Emuxol 268) were obtained. Taking into account the physical and chemical parameters, the most potent micellar emulsion for injection was selected and characterized. The emulsion based on Kolliphor ELP remains stable for 4 months, with no changes in the fluorescence spectrum and absorption, as well as the particle diameter.
ISSN:2413-9432
DOI:10.24931/2413-9432-2019-8-1-18-23