Phage as a source of antibacterial genes: Multiple inhibitory products encoded by Rhodococcus phage YF1

Bacteriophage-encoded proteins which inhibit or modify cellular components may contribute to antibacterial drug discovery by allowing the identification of novel targets. Given their abundance and diversity, phages may have various strategies in host inhibition and therefore may possess a variety of...

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Bibliographic Details
Published inBacteriophage Vol. 1; no. 4; pp. 195 - 197
Main Authors Shibayama, Youtaro, Dabbs, Eric R
Format Journal Article
LanguageEnglish
Published United States 01.07.2011
Subjects
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
Rhodococcus equi
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Summary:Bacteriophage-encoded proteins which inhibit or modify cellular components may contribute to antibacterial drug discovery by allowing the identification of novel targets. Given their abundance and diversity, phages may have various strategies in host inhibition and therefore may possess a variety of such proteins. Using Rhodococcus equi and phage YF1, we show that a single phage possesses numerous genes that inhibit the host when introduced into the host on a plasmid. These genes mostly encode proteins of unknown function, confirming the potential that this approach may have in providing new antibacterial targets.
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ISSN:2159-7073
2159-7081
2159-7081
DOI:10.4161/bact.1.4.17746