The role of antimicrobial peptides in defending the urinary tract against infections

With antibiotic resistance increasing and new microbial resistance factors forming, the problem of creating new methods to treat and prevent the urinary tract infections becomes topical. The latest studies showed that urothelium contains a large number of immune factors providing its protection agai...

Full description

Saved in:
Bibliographic Details
Published inMedicinskij sovet no. 2; pp. 143 - 150
Main Authors Zakharova, I. N., Osmanov, I. M., Klimov, L. Ya, Kasyanova, A. N., Kuryaninova, V. A., Lupan, I. N.
Format Journal Article
LanguageEnglish
Russian
Published Remedium Group LLC 16.02.2019
Subjects
antimicrobial peptides
biocenoses preserving therapy
canephron n
cathelicidin
defensins
inborn immunity
urinary tract infection
Online AccessGet full text

Cover

More Information
Summary:With antibiotic resistance increasing and new microbial resistance factors forming, the problem of creating new methods to treat and prevent the urinary tract infections becomes topical. The latest studies showed that urothelium contains a large number of immune factors providing its protection against the adverse effects of various uropathogens in vivo. There are very promising molecules – antimicrobial peptides (AMPs) – in terms of further therapeutic use among the components of inborn immunity. AMPs are the evolutionarily oldest molecules of innate immunity. The article discusses current data on the presence of various classes of AMPs in the urinary system, demonstrates data on their effectiveness as therapeutic agents against UTI, and describes further prospects for their use in the GP practice.
ISSN:2079-701X
2658-5790
DOI:10.21518/2079-701X-2019-2-143-150