Prostaglandin treatment of newborns with ductal-dependent congenital heart disease

• Published in: Pediatric annals Vol. 10; no. 4; pp. 29 - 38
• Main Authors: Linday, L A, Engle, M A
• Format: Journal Article
• Language: English
• Published: United States SLACK INCORPORATED 01.04.1981
• Subjects: Cardiac catheterization; Cardiovascular disease; Collaboration; Congenital diseases; Drug dosages; Ductus Arteriosus, Patent - drug therapy; Fatty acids; Heart; Heart Defects, Congenital - drug therapy; Heart Disorders; Humans; Infant, Newborn; Intubation; Neonates; Newborn babies; Organic Chemistry; Premature babies; Premature birth; Premature Infants; Prostaglandins E - therapeutic use; Pulmonary Circulation - drug effects; Pulmonary Valve Stenosis - drug therapy; Side effects; Sleep apnea; Transposition of Great Vessels - drug therapy; Young Children
• ISSN: 0090-4481; 1938-2359
• DOI: 10.3928/00904481-19810401-05

A major development in the field of neonatal heart disease over the past decade has been the attempt at salvage of the cyanotic newborn with critically severe congenital heart disease. What Prostaglandins are Prostaglandins are a group of naturally occurring, chemically related, 20-carbon hydroxy fatty acids that stimulate contractility of the uterine and other smooth muscle, can lower blood pressure, and affect the action of some hormones. The results of a collaborative study demonstrating this were presented a year ago at the meeting of the American Heart Association.18 At that time Dr. Michael Freed reported on data from more than 300 infants treated with PGE1 infusions because of restricted pulmonary blood flow. Patient Diagnosis Age at initial treatment pO2 (mm. Hg.) Response Survival Before PGE1 During PGE1 Effective Not Effective Questionably Effective 1 Pulmonary atresia and ventricular septal defect 32 hours 21 36 X Living 2 Pulmonary atresia, ventricular septal defect, atypical patent ductus 18 hours 33 31 X Living 3 Tricuspid atresia 14 hours 23 33 X Living 4 Pulmonary atresia, intact ventricular septum, hypoplastic right ventricle, restrictive atrial septal defect 20 days 28 35 X Living 5 Pulmonary atresia, intact ventricular septum, dextrocardia, situs inversus 17 hours 21 33 X Living 6 Severe pulmonic stenosis with hypo plastic right ventricle, intact ventricular septum; ductus arteriosus closed at cardiac catheterization 4.5 days 30–70 50–75 X Late death 7 Pulmonary atresia, intact ventricular septum, small right ventricle 14 hours 21 38 X Early death 8 Pulmonary atresia, mitral stenosis, l-transposition