Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

• Published in: European journal of medicinal chemistry Vol. 264; p. 116043
• Main Authors: Ravindar, Lekkala, Hasbullah, Siti Aishah, Rakesh, K P, Raheem, Saki, Agustar, Hani Kartini, Ismail, Norzila, Ling, Lau Yee, Hassan, Nurul Izzaty
• Format: Journal Article
• Language: English
• Published: France 15.01.2024
• Subjects: Aminoquinolines - chemistry; Aminoquinolines - pharmacology; Antimalarials - pharmacology; Plasmodium falciparum; Quinolines - pharmacology; Structure-Activity Relationship; Antimalarial; 4-Aminoquinolines; Antibacterial; Anticancer; Antitubercular
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2023.116043

Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21 century. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities.