Epigenetic regulations in Mycobacterium tuberculosis infection

Mycobacterium tuberculosis (Mtb) employs several sophisticated strategies to evade host immunity and facilitate its intracellular survival. One of them is the epigenetic manipulation of host chromatin by three strategies i.e., DNA methylation, histone modifications and miRNA involvement. A host-dire...

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Bibliographic Details
Published inIndian journal of tuberculosis Vol. 71; no. 2; pp. 204 - 212
Main Authors Wazahat, Rushna, Zaidi, Rana, Kumar, Pankaj
Format Journal Article
LanguageEnglish
Published India Elsevier B.V 01.04.2024
Subjects
Chromatin - metabolism
Epigenesis, Genetic
Epigenetics
Gene Expression Regulation
Histones
Humans
Immunity
miRNA
Mycobacterium tuberculosis
Tuberculosis - drug therapy
Epigenetics
Histones
miRNA
Mycobacterium tuberculosis
Immunity
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Summary:Mycobacterium tuberculosis (Mtb) employs several sophisticated strategies to evade host immunity and facilitate its intracellular survival. One of them is the epigenetic manipulation of host chromatin by three strategies i.e., DNA methylation, histone modifications and miRNA involvement. A host-directed therapeutic can be an attractive approach that targets these host epigenetics or gene regulations and circumvent manipulation of host cell machinery by Mtb. Given the complexity of the nature of intracellular infection by Mtb, there are challenges in identifying the important host proteins, non-coding RNA or the secretory proteins of Mtb itself that directly or indirectly bring upon the epigenetic modifications in the host chromatin. Equally challenging is developing the methods of targeting these epigenetic factors through chemical or non-chemical approaches as host-directed therapeutics. The current review article briefly summarizes several of the epigenetic factors that serve to bring upon potential changes in the host transcriptional machinery and targets the immune system for immunosuppression and disease progression in Mtb infection. •Mycobacterium tuberculosis (Mtb) employs epigenetic changes in the host cell for survival.•DNA methylation affects gene expression in the host cell.•Few M.tb proteins interact directly/indirectly with host histones.•Non-coding RNAs play rolesin autophagy, apoptosis, cytokine regulation, NO suppression etc.
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ISSN:0019-5707
DOI:10.1016/j.ijtb.2023.06.011