GWAS-based polygenic risk scores for depression with clinical validation: methods and study design in the Russian population

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 120; no. 11; p. 131
• Main Authors: Kibitov, A O, Mazo, G E, Rakitko, A S, Kasyanov, E D, Rukavishnikov, G V, Ilinsky, V V, Golimbet, V E, Shmukler, A B, Neznanov, N G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2020
• Subjects: Depression - epidemiology; Depression - genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Multifactorial Inheritance; Quality of Life; Risk Factors; Russia - epidemiology; Russia; population study; preventive healthcare; genome-wide association study; genetic risks; depression; prevention; polygenic risk scores
• ISSN: 1997-7298
• DOI: 10.17116/jnevro2020120111131

Depression is one of the leading causes of decreased quality of life and social functioning of patients. In the context of preventive medicine, the prevention of depression becomes a priority. To achieve the goals of prevention, it is necessary to identify specific population risk groups - individuals with a high genetic risk of depression. The paper describes the project aimed at developing a genetic test system based on polygenic risk scores (PRS) for depression, considering the multi-ethnicity and multicultural diversity of the Russian population. As a result of the study, data on the genetic architecture of depression (GWAS) and PRS for depression will be obtained for the first time. The emergence of a genetic test system developed in the study of the Russian population and in the conditions of a constant decrease in the cost of genetic research will allow an effective transition to preventive medicine in the area of mental health.