TNFα-308G>A Polymorphism and Susceptibility to Immune Thrombocytopenia Purpura (ITP): Evidence From a Systematic Review and Meta-analysis

• Published in: Cytokine (Philadelphia, Pa.) Vol. 177; p. 156538
• Main Authors: Shams, Seyyede Fatemeh, Mehrad-Majd, Hassan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2024
• Subjects: Genetic Predisposition to Disease; Genetic variation; Heterozygote; Humans; Polymorphism, Single Nucleotide - genetics; Purpura, Thrombocytopenic, Idiopathic - genetics; Thrombocytopenia; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha - genetics; Thrombocytopenia; Genetic variation; Tumor Necrosis Factor-alpha
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1016/j.cyto.2024.156538

Relation between the emergence of ITP and the presence of TNFα 308G/A polymorphism in the involved individuals has been studied by previous researchers in different ethnicity, but a definite result was not gained. So, this meta-analysis was performed to find an absolute answer to the question whether TNF-α-308G/A polymorphism is a susceptibility factor for ITP or not? Electronic databases including PubMed, Google scholar, and Science Direct were searched and case control studies compatible to the defined inclusion criteria were selected; their references were also evaluated manually. Pooled OR with 95 % confidence intervals (CIs) as a strength of association between TNF-α-308G/A polymorphism and risk of ITP were calculated using a random-effect model. Funnel plot and Egger’s linear regression test were conducted to examine the risk of publication bias. Totally, 16 eligible articles were found involving 1470 ITP cases and 2324 healthy controls. The Meta-results revealed that TNFα 308G/A polymorphism is associated with increased risk of ITP under the genetic models of recessive (OR: 1.54, 95 % CI: 1.03–2.29), dominant (OR: 2.29, 95 % CI: 1.44–3.64), and the heterozygote (OR: 2.46, 95 % CI:1.49–4.6). Subgroup analysis suggested a remarkable role for this SNP as a risk factor in the Caucasian ethnicity and the chronic subtype. TNFα 308G/A polymorphism can be an ITP susceptibility factor in the Caucasian population and the chronic subtype. Although more studies in large scale are needed for clinical decision but this finding can be used in the clinical trials to prevent the ITP consequences in the involved individuals.