NHC-alcohol adduct-mediated photocatalytic deoxygenation for the synthesis of 6-phenanthridine derivatives

NHC-alcohol adduct-mediated deoxygenation of alcohols under photocatalytic conditions is described. This process provides various alkyl radicals, which can react with 2-isocyanobiaryls to afford 6-substituted phenanthridine derivatives in moderate to good yields. This method offered the first exampl...

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Published inOrganic & biomolecular chemistry Vol. 20; no. 27; pp. 5393 - 5396
Main Authors Ma, Xueji, Wang, Qingyun, Wu, Jinge, Zhang, Liyuan, Sun, Aili, Wang, Zhanyong
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 13.07.2022
Royal Society of Chemistry
Subjects
Alcohols
Chemistry
Chemistry, Organic
Deoxygenation
Phenanthridine
Physical Sciences
Science & Technology
Synthesis
2-ISOCYANOBIPHENYLS
PHENANTHRIDINE DERIVATIVES
ARYLATION
SANGUINARINE
ANTITUMOR
CYCLIZATION
OXALATES
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Summary:NHC-alcohol adduct-mediated deoxygenation of alcohols under photocatalytic conditions is described. This process provides various alkyl radicals, which can react with 2-isocyanobiaryls to afford 6-substituted phenanthridine derivatives in moderate to good yields. This method offered the first example of directly using alcohols as radical sources for 6-phenanthridine synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob00814a