New non-peptide angiotensin II receptor antagonists. 2: structure - activity relationship of a series of annelated 2(1H)-pyridinones

The synthesis and angiotensin II antagonist activity of biphenyl tetrazole substituted fused bicyclic analogues of 2-pyridinone is described. Potent antagonist activity was found in the 2-quinolinone, thieno[2,3-b] pyridine and imidazo[c]pyridine series. The synthesis and angiotensin II antagonist a...

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Published inBioorganic & medicinal chemistry letters Vol. 4; no. 1; pp. 127 - 132
Main Authors Bantick, John R., Beaton, Haydn G., Cooper, Sally L., Hill, Stephen, Hirst, Simon C., McInally, Tom, Spencer, Jane, Tinker, Alan C., Willis, Paul A.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1994
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Summary:The synthesis and angiotensin II antagonist activity of biphenyl tetrazole substituted fused bicyclic analogues of 2-pyridinone is described. Potent antagonist activity was found in the 2-quinolinone, thieno[2,3-b] pyridine and imidazo[c]pyridine series. The synthesis and angiotensin II antagonist activity of biphenyltetrazole- substituted, fused bicyclic analogues of 2-pyridinone is described. Particularly potent antagonist activity was found for quinolones (I), thienopyridone (II) and imidazopyridones (III).
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)81134-3