LGI1 positive paraneoplastic limbic encephalitis: A case report of atypical presentation

Limbic encephalitis is a rare disorder mainly affecting the medial temporal lobe and is classically paraneoplastic. Autoimmune etiologies also exist, such as antibodies against leucine-rich glioma activated 1 (LGI1). Most cases of anti-LGI1 encephalitis are not associated with tumors. Subacute memor...

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Published inNeurology Asia Vol. 26; no. 4; pp. 865 - 867
Main Authors Cheng, Chien-Chung, Sung, Jia-Ying, Huang, Chih-Shan
Format Journal Article
LanguageEnglish
Published 01.12.2021
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Summary:Limbic encephalitis is a rare disorder mainly affecting the medial temporal lobe and is classically paraneoplastic. Autoimmune etiologies also exist, such as antibodies against leucine-rich glioma activated 1 (LGI1). Most cases of anti-LGI1 encephalitis are not associated with tumors. Subacute memory loss is the predominant feature, and most patients develop focal seizures, especially faciobrachial dystonic seizures (FBDSs). Immunotherapies usually show a good response, but are less effective in paraneoplastic cases. We report a case of steroid-responsive anti-LGI1 encephalitis with atypical presentations of sensory aphasia during relapse from rectal carcinoma, an atypical site.
ISSN:1823-6138
DOI:10.54029/2021auz