Carcinoma of the tongueand floor of the mouth preliminary results of a multidisciplinary approach

• Published in: Journal of maxillofacial surgery Vol. 13; pp. 111 - 115
• Main Authors: Airoldi, Mario, Fazio, Massimo, Gandolfo, Sergio, Ozzello, Franca, Pedani, Fulvia
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 1985
• Subjects: Chemotherapy; Cryosurgery; Follow up; Oral cavity tumours; Radiotherapy; Surgery; Chemotherapy; Follow up; Cryosurgery; Radiotherapy; Surgery; Oral cavity tumours
• ISSN: 0301-0503
• DOI: 10.1016/S0301-0503(85)80028-X

Eighty-five patients (74 males, 11 females) with untreated squamous-cell carcinoma of the tongue (40 patients) and the floor of the mouth (45 patients) underwent a multidisciplinary treatment. Follow-up: 6–72 months (median 52 months). T1–4N0M0 lesions (tongue; 32 patients; floor of mouth, 32 patients) were treated with cryosurgery (T1–2: 1–2 sessions, T3–4: 2–4 sessions) and contemporaneously with CMF (cyclophosphamide, methotrexate, fluorouracil) (T1–2: 2 courses; T3–4: 3 courses). 15–20 days after the end of cryo-chemotherapy the patients underwent TCT (T1: 50 Gy to the tumour and lymph nodes; T2–3–4: same with an extra dose of 10–15 Gy to the primary lesion). T1–4N1–3M0 patients (tongue: 8, floor of mouth: 13)received the same cryotherapy and chemotherapy, followed by surgery (13 extended suprahyoid dissections, 8 conservative laterocervical dissections, 1 RND). The actuarial survival rate of patients with tonguetumours after 6 years was 81.4 % (No 87.1 %; N+ 60.0 %). Four months after treatment, 35 patients had reached complete remission (CR). The probability of remaining in CR for 6 years was 53.6 % (No 56.1 %; N+ 50.0 %). For tumours of the floor of the mouth the actuarialsurvival rate was 55.2 % (No 56.5 %; N+ 48.6 %). Four months after treatment, 38 patients had reached CR. The probability of remaining in CR for 6 years was 59.9 % (No 61.5 %; N+ 59.3 %). A controlled study is recommended in the light of theseresults and the conservative nature of the protocol.