Rebound neovascularization during bevacizumab therapy

To present two cases of rebound neovascularization after bevacizumab treatment. Observational, retrospective case report. A 42-year-old male patient with proliferative diabetic retinopathy and a 68-year-old man with central retinal vein occlusion received treatment with panretinal photocoagulation a...

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Bibliographic Details
Published inRetinal cases & brief reports Vol. 4; no. 3; p. 216
Main Authors Garcia-González, José M, Berrocal, Maria
Format Journal Article
LanguageEnglish
Published United States 2010
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Summary:To present two cases of rebound neovascularization after bevacizumab treatment. Observational, retrospective case report. A 42-year-old male patient with proliferative diabetic retinopathy and a 68-year-old man with central retinal vein occlusion received treatment with panretinal photocoagulation and intravitreal bevacizumab. Both patients showed significant improvement with regression of neovascular vessels after treatment. Nevertheless, on cessation of treatment because of loss to follow-up, both presented with massive neovascularization. This was significantly more severe than the initial presentation. After initial suppression of vascular endothelial growth factor by bevacizumab, a rebound phenomenon of neovascularization can occur.
ISSN:1935-1089
DOI:10.1097/ICB.0b013e3181af5596