Novel Approaches to Patients with Differences of Sex Development

• Published in: Advances in pediatrics Vol. 71; no. 1; pp. 151 - 167
• Main Authors: Ochoa, Brielle, Weidler, Erica M., Parks, Melissa A., Speck, Karen Elizabeth, van Leeuwen, Kathleen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2024
• Subjects: Differences of sex development (DSDs); Disorders of Sex Development - diagnosis; Female; Humans; Infant, Newborn; Male; Mullerian anomaly; Outflow tract obstruction (OTO); Plastic Surgery Procedures - methods; Reconstruction; Shared decision-making; Vagina - surgery; Vaginoplasty; Reconstruction; Differences of sex development (DSDs); Mullerian anomaly; Vaginoplasty; Outflow tract obstruction (OTO); Shared decision-making
• ISSN: 0065-3101; 1878-1926; 1878-1926
• DOI: 10.1016/j.yapd.2024.04.002

Patients with differences of sex development (DSDs) have complex anatomy and surgical needs related to both Mullerian and non-Mullerian structures. Approaches to vaginal reconstruction for these conditions are guided by individual anatomy, with the goal of establishing unobstructed outflow for the reproductive, urinary, and gastrointestinal tracts. Patients may have anatomy requiring vaginoplasty for either outflow tract obstruction or chosen sexual function. In this article, the authors focus on management of differences in vaginal anatomy with delayed vaginoplasty for the newborn with DSD.