Effect of transforming growth factor- β1 on interleukin-6 secretion in human myoblasts

• Published in: Journal of neuroimmunology Vol. 87; no. 1; pp. 185 - 188
• Main Authors: Mazzarelli, Paola, Scuderi, Flavia, Mistretta, Guido, Provenzano, Carlo, Bartoccioni, Emanuela
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.1998
• Subjects: Gene therapy; Inflammatory myopathies; Interleukin-1 β (IL-1 β); Interleukin-6 (IL-6); Myoblasts; Transforming growth factor beta (TGF- β); Inflammatory myopathies; Interleukin-1 β (IL-1 β); Interleukin-6 (IL-6); Gene therapy; Transforming growth factor beta (TGF- β); Myoblasts
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/S0165-5728(98)00110-6

Transforming growth factor- β (TGF- β) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts secrete interleukin-6 (IL-6) when stimulated with inflammatory cytokine such as interleukin-1 β (IL-1 β) or tumor necrosis factor α. In the present report, we show that TGF- β1 can induce IL-6 production; moreover, costimulation or short term pre-incubation with TGF- β1 increases IL-1 β effect, while a longer incubation inhibits its action.