Density, ultrasonic velocity and viscosity measurements of four pharmacologically significant drugs in methanol at 25°C
Density, ultrasonic velocity and viscosity of four pharmaceutically significant drugs were measured in methanol at 25°C. The apparent molar volume (∅ v), apparent molar compressibility (∅ K) and the viscosity B-coefficient were calculated from the experimental data. The variation of ∅ v and ∅ K with...
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Published in | Journal of molecular liquids Vol. 75; no. 1; pp. 33 - 43 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
1998
|
Online Access | Get full text |
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Summary: | Density, ultrasonic velocity and viscosity of four pharmaceutically significant drugs were measured in methanol at 25°C. The apparent molar volume (∅
v), apparent molar compressibility (∅
K) and the viscosity B-coefficient were calculated from the experimental data. The variation of ∅
v and ∅
K with a drug concentration is linear. Values of ∅
vo and ∅
Ko are used to understand solute-solvent interactions. ∅
vo and B-coefficient show wide divergence depending on the size, shape and structure of a drug, while ∅
Ko are close to each other for all the four molecules. The first two parameters show differential solute-solvent interactions, while ∅
Ko show that the drugs compress the solvent to the same extent. This observation is supported by B/∅
vo and solvation numbers (S
n) of the drugs. |
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ISSN: | 0167-7322 1873-3166 |
DOI: | 10.1016/S0167-7322(97)00021-4 |