Theranostics: From PET imaging to radioisotope therapy
Theranostics is an innovative medical technology that integrates both therapeutic and diagnostic capabilities, allowing seamless transition from imaging diagnosis to radioisotope therapy by altering the radionuclide label on the same compound. This approach enables not only the quantitative assessme...
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| Published in | Drug Delivery System Vol. 40; no. 1; pp. 54 - 61 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
Kawasaki
THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
25.01.2025
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0913-5006 1881-2732 |
| DOI | 10.2745/dds.40.54 |
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| Abstract | Theranostics is an innovative medical technology that integrates both therapeutic and diagnostic capabilities, allowing seamless transition from imaging diagnosis to radioisotope therapy by altering the radionuclide label on the same compound. This approach enables not only the quantitative assessment of target molecule expression in diagnostic imaging but also the prediction of therapeutic efficacy. In the drug discovery process, theranostics provides insights into the biodistribution of diagnostic agents, facilitating the optimization of therapeutic agents. This optimization can reduce physiological accumulation in normal organs, thereby minimizing potential side effects. Japan has taken a leading role globally in developing and clinically applying theranostics using astatine（211At）, a radionuclide that can be produced using cyclotrons. The advancement of 211At-based drug development offers significant potential for future theranostic applications, with expectations for expanded clinical use and therapeutic innovation. |
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| AbstractList | Theranostics is an innovative medical technology that integrates both therapeutic and diagnostic capabilities, allowing seamless transition from imaging diagnosis to radioisotope therapy by altering the radionuclide label on the same compound. This approach enables not only the quantitative assessment of target molecule expression in diagnostic imaging but also the prediction of therapeutic efficacy. In the drug discovery process, theranostics provides insights into the biodistribution of diagnostic agents, facilitating the optimization of therapeutic agents. This optimization can reduce physiological accumulation in normal organs, thereby minimizing potential side effects. Japan has taken a leading role globally in developing and clinically applying theranostics using astatine（211At）, a radionuclide that can be produced using cyclotrons. The advancement of 211At-based drug development offers significant potential for future theranostic applications, with expectations for expanded clinical use and therapeutic innovation. |
| Author | Watabe, Tadashi |
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| Copyright | 2025 The Japan Society of Drug Delivery System Copyright Japan Science and Technology Agency 2025 |
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| References | 13）Watabe T, et al., J. Nucl. Med., 61, 563-569 （2020 4）Kratochwil C, et al., J. Nucl. Med., 57, 1941-1944 （2016 15）Watabe T, et al., J. Nucl. Med., 64, 1949-1955 （2023 12）Kaneda-Nakashima K, et al., Cancer Sci., 112, 1132-1140 （2021 14）Aso A, et al., Int. J. Mol. Sci., 24, 8701 （2023 3）Howell RW, et al., Radiat. Res., 137, 352-360 （1994 5）Watabe T, et al., J. Nucl. Med., 60, 1301-1307 （2019 9）Watabe T, et al., Eur. J. Nucl. Med. Mol. Imaging, 50, 849-858 （2023 7）Naka S, et al., EJNMMI Radiopharm. Chem., 15, 29 （2024 1）Akatani N, et al., Endocr. J., 70, 315-322 （2023 6）Watabe T, et al., Int. J. Mol. Sci., 23, 9434 （2022 10）Watabe T, et al., Int. J. Mol. Sci., 25, 5667 （2024 11）Watabe T, et al., Oncotarget, 11, 1388-1398 （2020 2）Watabe T, et al., Ann. Nucl. Med., 35, 523-528 （2021 8）Sartor O, et al., N. Engl. J. Med., 385, 1091-1103 （2021 |
| References_xml | – reference: 11）Watabe T, et al., Oncotarget, 11, 1388-1398 （2020） – reference: 13）Watabe T, et al., J. Nucl. Med., 61, 563-569 （2020） – reference: 14）Aso A, et al., Int. J. Mol. Sci., 24, 8701 （2023） – reference: 15）Watabe T, et al., J. Nucl. Med., 64, 1949-1955 （2023） – reference: 4）Kratochwil C, et al., J. Nucl. Med., 57, 1941-1944 （2016） – reference: 1）Akatani N, et al., Endocr. J., 70, 315-322 （2023） – reference: 9）Watabe T, et al., Eur. J. Nucl. Med. Mol. Imaging, 50, 849-858 （2023） – reference: 7）Naka S, et al., EJNMMI Radiopharm. Chem., 15, 29 （2024） – reference: 8）Sartor O, et al., N. Engl. J. Med., 385, 1091-1103 （2021） – reference: 10）Watabe T, et al., Int. J. Mol. Sci., 25, 5667 （2024） – reference: 12）Kaneda-Nakashima K, et al., Cancer Sci., 112, 1132-1140 （2021） – reference: 3）Howell RW, et al., Radiat. Res., 137, 352-360 （1994） – reference: 2）Watabe T, et al., Ann. Nucl. Med., 35, 523-528 （2021） – reference: 6）Watabe T, et al., Int. J. Mol. Sci., 23, 9434 （2022） – reference: 5）Watabe T, et al., J. Nucl. Med., 60, 1301-1307 （2019） |
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| Title | Theranostics: From PET imaging to radioisotope therapy |
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