Theranostics: From PET imaging to radioisotope therapy

Theranostics is an innovative medical technology that integrates both therapeutic and diagnostic capabilities, allowing seamless transition from imaging diagnosis to radioisotope therapy by altering the radionuclide label on the same compound. This approach enables not only the quantitative assessme...

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Bibliographic Details
Published inDrug Delivery System Vol. 40; no. 1; pp. 54 - 61
Main Author Watabe, Tadashi
Format Journal Article
LanguageJapanese
Published Kawasaki THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 25.01.2025
Japan Science and Technology Agency
Subjects
alpha therapy
Astatine
Cyclotrons
Diagnostic agents
Drug development
Medical imaging
Medical innovations
Medical technology
Optimization
PET
Pharmacology
Physiological effects
Positron emission
Precision medicine
PSMA
Radioisotopes
Side effects
Theranostics
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ISSN0913-5006
1881-2732
DOI10.2745/dds.40.54

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Summary:Theranostics is an innovative medical technology that integrates both therapeutic and diagnostic capabilities, allowing seamless transition from imaging diagnosis to radioisotope therapy by altering the radionuclide label on the same compound. This approach enables not only the quantitative assessment of target molecule expression in diagnostic imaging but also the prediction of therapeutic efficacy. In the drug discovery process, theranostics provides insights into the biodistribution of diagnostic agents, facilitating the optimization of therapeutic agents. This optimization can reduce physiological accumulation in normal organs, thereby minimizing potential side effects. Japan has taken a leading role globally in developing and clinically applying theranostics using astatine（211At）, a radionuclide that can be produced using cyclotrons. The advancement of 211At-based drug development offers significant potential for future theranostic applications, with expectations for expanded clinical use and therapeutic innovation.
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ISSN:0913-5006
1881-2732
DOI:10.2745/dds.40.54