Effects of radiation-induced suicide gene therapy under radiation of radionuclide 125I on human hepatocarcinoma cells in vitro

• Published in: Chinese medical journal Vol. 127; no. 7; pp. 1385 - 1387
• Main Authors: Li, Ling, Zhang, Chunli, Yan, Ping, Yin, Lei, Kang, Lei, Zhao, Qian, Wang, Rongfu
• Format: Journal Article
• Language: English
• Published: China Department of Nuclear Medicine, Peking University First Hospital,Beijing 100034, China%Department of Nuclear Medicine, Peking University First Hospital,Beijing 100034, China 2014; Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China
• Subjects: Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - therapy; Cytosine Deaminase - genetics; Genetic Therapy - methods; Hep G2 Cells; HepG2细胞; Humans; Liver Neoplasms - genetics; Liver Neoplasms - therapy; Promoter Regions, Genetic; 人肝癌细胞; 体外; 单克隆抗体; 基因疗法; 放射性核素; 胞嘧啶脱氨酶; 辐射诱导; fluorocytosine; cytosine deaminase; promoter regions,genetic lentivirus; HepG2 cells; radiation effects
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20131185

There are few efficient therapeutic approaches to hepatocarcinoma.Chen et al1 developed iodine （131I） metuximab injection （Licartin）,a novel 131I-labeled HAb18G/CD147-specific monoclonal antibody Fab＇2 fragment.HAb18G/CD147 is a hepatocellular carcinoma-associated antigen.But their results have no obvious improvements in survival rate of patients with hepatocarcinoma.Keywords：radiation effects; promoter regions, genetic lentivirus; cytosine deaminase; fluorocytosine; HepG2 cells