Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed Csp2–H activation/arylation approach

[Display omitted] A facile and efficient synthetic approach under the catalyst system of Pd(OAc)2/KOAc/TBAB/DMF was developed allowing for rapid preparation of 2-arylation derivatives of the natural product tanshinone I. This approach was featured by palladium-catalyzed C–C coupling through direct C...

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Bibliographic Details
Published inTetrahedron letters Vol. 56; no. 21; pp. 2799 - 2802
Main Authors Jiao, Mingkun, Ding, Chunyong, Zhang, Ao
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 20.05.2015
Subjects
Anticancer
C–H activation
Direct arylation
Palladium
Tanshinone I
Direct arylation
C–H activation
Palladium
Anticancer
Tanshinone I
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Summary:[Display omitted] A facile and efficient synthetic approach under the catalyst system of Pd(OAc)2/KOAc/TBAB/DMF was developed allowing for rapid preparation of 2-arylation derivatives of the natural product tanshinone I. This approach was featured by palladium-catalyzed C–C coupling through direct Csp2–H activation at the α-position of the furan ring of tanshinone I. Compared to the literature procedures, our protocol exhibited better atom-economy and much improved yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.04.040