SnCl2·2H2O as a precatalyst in MCR: synthesis of pyridine derivatives via a 4-component reaction in water

[Display omitted] For the first time SnCl2·2H2O has been identified as a convenient precatalyst for the synthesis of pyridine derivatives via an MCR in water. The 4-component reaction of alkyl/(hetero)aryl aldehydes, β-keto esters (or 1,3-diketones), anilines, and malononitrile afforded a range of n...

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Bibliographic Details
Published inTetrahedron letters Vol. 56; no. 31; pp. 4586 - 4589
Main Authors Reddy, Dinne Naresh Kumar, Chandrasekhar, Kothapalli Bannoth, Ganesh, Yaddanapudi Sesha Siva, Sathish Kumar, Burra, Adepu, Raju, Pal, Manojit
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 29.07.2015
Subjects
MCR
Pyridine
SnCl2
Water
Water
SnCl2
Pyridine
MCR
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Summary:[Display omitted] For the first time SnCl2·2H2O has been identified as a convenient precatalyst for the synthesis of pyridine derivatives via an MCR in water. The 4-component reaction of alkyl/(hetero)aryl aldehydes, β-keto esters (or 1,3-diketones), anilines, and malononitrile afforded a range of new polysubstituted pyridines including 4-alkyl/heteroaryl derivatives in 78–91% yields. The use of less expensive catalyst in aqueous media and good yields of products with wider substrate scope are the key features of this methodology.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.06.008