α2δ and the mechanism of action of gabapentin in the treatment of pain

Gabapentin is a drug that has been widely used in the treatment of chronic pain states. Despite its widespread usage, it is only recently that light has been shed on the mechanism of action of this agent. In the current review, the authors document the pharmacological, biochemical and molecular info...

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Bibliographic Details
Published inSeminars in cell & developmental biology Vol. 17; no. 5; pp. 565 - 570
Main Authors Maneuf, Y.P., Luo, Z.D., Lee, K.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2006
Subjects
Gabapentin
Lyrica
Neurontin
Pain
Pregabalin
Review
Voltage gated calcium channel
Pain
Gabapentin
Neurontin
GAT1
Voltage gated calcium channel
GABA
DRG
Review
Pregabalin
Lyrica
α2δ
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Summary:Gabapentin is a drug that has been widely used in the treatment of chronic pain states. Despite its widespread usage, it is only recently that light has been shed on the mechanism of action of this agent. In the current review, the authors document the pharmacological, biochemical and molecular information that has led to the identification of the α2δ1 auxilliary subunit of voltage gated calcium channels as the target for this drug's actions.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2006.09.003