Biodegradation of diclofenac with fungal strains

Diclofenac (2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid) is a non-steroidal anti-infl ammatory drug. Due to excessive use of diclofenac, this drug has been detected in surface water, ground water and drinking water. In our study, four fungal strain Trametes trogii, Aspergillus niger, Yarrowia li...

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Bibliographic Details
Published inArchives of environmental protection Vol. 44; no. 1
Main Authors Aracagök, Y Doruk, Göker, Hakan, Cihangir, Nilüfer
Format Journal Article
LanguageEnglish
Published Warsaw Polish Academy of Sciences 01.01.2018
Subjects
Biodegradation
Cytochrome
Cytochrome P450
Cytochromes P450
Diclofenac
Drinking water
Fungi
Groundwater
Laccase
Metabolites
Microtox
Nonsteroidal anti-inflammatory drugs
Surface water
Surface-groundwater relations
Toxicity
Trametes trogii
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Summary:Diclofenac (2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid) is a non-steroidal anti-infl ammatory drug. Due to excessive use of diclofenac, this drug has been detected in surface water, ground water and drinking water. In our study, four fungal strain Trametes trogii, Aspergillus niger, Yarrowia lipolytica and Phanerochaete chrysosporium were investigated in terms of diclofenac degradation potential. Trametes trogii was found to be the most effi cient strain with 100% diclofenac degradation rate. Two hydroxylated diclofenac metabolites have been identifi ed in culture medium. Crude laccase from T. trogii almost completely removed diclofenac with 97% removal in 48 h. We suggest that the degradation of diclofenac depends on the cytochrome P450 enzyme system and laccase activity. After 24 h incubation decrease in toxicity of diclofenac was confi rmed by Microtox test.
ISSN:2083-4772
2083-4810
DOI:10.24425/118181